Pharmacotherapy Lectures: Need your valuable insights

Dear All PharmD's,
Act today for better tomorrow. Need your valuable support and it's important for a better profession for representation.

Since few years, we are striving for the better profession to become equally competent with the western world. In this regard, we had conversations with our Honorable Prime Minister Shri. Narendra Modi Ji, Central and State Ministries. Our request is accepted and soon the issues of unemployment will be addressed. It is very important for us to even think of the quality of PharmD Education in India.

What have we done till date??
1) We addressed the issue and importance of scholarly research in India and revealed the results for discussion.
2) We addressed the importance of Preceptorship and bedside teaching and discussed with resource persons of American Colleges of Clinical Pharmacy (ACCP), USA.
3) We discussed the issue of unemployment with respective state and Central Ministries, certain issues are already represented by the Central Minister J.P. Nadda in the World Health Assembly.
4) We are also a part of various International Organisations and platforms like ACCP, FIP, USAID, WHO, European Nations, South African, Asian and Gulf Nations representing Indian PharmD globally.
5) We are conducting various interactive programmes among countries and are part of Global research representing Indian PharmD.



What is this initiative about??
As Pharmacotherapy is the soul of PharmD it is important to raise our standards to become enough competent. PharmD is highly sophisticated in the West and hence they've developed 114 Specialities and employed 1000's of Clinical Pharmacists. We are ought to be on the same path and improve our professional standards. Hence we need to know our present education system and quality of Pharmacotherapy lectures. Let us know your valuable inputs by just sparing 5 -10 min, we shall invest our time, money and energy to address your inputs at the right platform for better future.

Why do you need to contribute ??
Excellence comes only when you learn from failures. Tomorrow will be better only if we know the mistakes of today. Unless we come forward and express what we are learning, it cannot be improved. If there is no improvement, there will be no employment.

Being a student how can you contribute ??Simply spare 5 -10min and fill your inputs about the Pharmacotherapy lectures in this survey form. We shall scrutinise, analyse and come out by addressing the flaws with valuable suggestions from experts to update ourselves.

Where is the survey form and is it validated ??
Yes, it has been reviewed by experts from 6 countries and here is the link :

https://ap1trial.qualtrics.com/jfe/form/SV_7O4gvryLLerxkO1

Thanking you in anticipation. Wish you all the best for you future endeavours.

Regards,
Dr. Deepak Kumar Bandari, PharmD,(PhD) Europe
Elsevier Student Ambassador and Mentor - South Asia
Winner - Ideathon - Nobel Prize Series -2017
For more updates join us on Telegram: @drdeepakbandari

Story of Success - Published by Elsevier

Dear Readers,

Thank you for blogging with us. I'm glad to share my story of success published by Elsevier.Thank you #ElsevierIndia for your kind encouragement. 

Nobel Prize Series : India

I'm elated to share an article published regarding my achievement in Indian Pharmaceutical Association (IPA) CPD e-times today, Vol 6, Issue 2, page 12. Thanks to Mrs. Manjiri Gharat, for recognising my efforts and encouraging young pharmacists. Credits: Dr. AkshayaSrikanth, the man behind my success, Prof. Y. Madhusudan Rao, the Legend behind my strength.

Swachh Pharmacy : Request to all the Pharmacists

A Humble request to all the Pharmacy Fraternity..!!!

Dear Pharmacy Professionals, 

I'm writing this to you with due respect to spare 2min of your valuable time for a better cause of our profession. 

For a Better Profession

I'm Dr. Deepak Kumar, PharmD; from Vaagdevi College of Pharmacy, Warangal; a Noble Prize Series Winner - 2017, as a part of this series (January 9 -13, 2017), I have an opportunity to meet our Honourable Prime Minister Shri. Narendra Modi Ji and I would like to submit a representation on behalf of all Pharmacy Fraternity. 

We are making sincere efforts to incorporate all the issues of our profession, a clear draft is being made with a request to introduce the strategies that could improve the quality of profession in all areas for Future Generation Pharmacists with a motto of "Swachh Pharmacy". 

As you all are well experienced and are expertise in Pharmacy Education, I request you all to come out with suggestions and discuss problems you have come across in your career. We shall all work together for a better profession that could help us grow and build a platform to be an Eight Star Pharmacist (WHO concept). 

Please share all your professional emotions, feelings, strategies and suggestions that could add a valuable point in our draft. Kindly write an email to us (no later than 5th January 2017): laxmideepak.pharma@gmail.com

Kindly share this message among all the pharmacists.

Thanking you in anticipation.

Regards, 

Dr.Deepak Kumar Bandari, PharmD 

Elsevier Student Ambassador for South Asia.

Case presentation - SOAPME* format

Here is the Case presentation in SOAPME* format highlighting the prescriptive role of Clinical Pharmacist in Ambulatory and Critical care. 

Download Full Presentation Here

8 Rejected Papers That Won the Nobel Prize

Nobel prize winning ideas are not always accepted by the community. By definition, they are paradigm shifting, revolutionary. Accordingly, many breakthroughs that are in our textbooks today were initially rejected, if not ridiculed, by the scientific community. Howard Temin proposed a reversal of the central dogma, wherein RNA could create DNA. It was called "ludicrous" and his Nobel "came after a lonely battle to overcome derisive criticism from scientific leaders who refused to believe in his theory that some viruses carry their genetic information in the form of RNA, which is then copied into DNA in infected cell." Similarly, Werner Arber, the scientist who discovered restriction enzymes worked, "in a climate of almost total indifference, notably that of the committees and organizations tasked with allocating funds for research" Jacob 1998.

Here we outline 8 Nobel prize papers that were initially rejected by anonymous pre-publication peer review and ask, "What Nobel ideas are we rejecting and/or delaying today?"

1. Nobel Prize in Chemistry (1997) awarded to Paul Boyer for: Identification of the mechanism for the synthesis of adenosine triphosphate (ATP)

Rejection: Boyer had been greeted with disbelief when he theorized that the previously mysterious process is the work of a "beautiful little machine" that operates within enzymes on the molecular level. His proposed resolution of a major unsolved problem in biochemistry threatened to "change the paradigm," Boyer remembers, and "the leading journal" in his field -The Journal of Biological Chemistry-declined to publish his work. 

Paul Boyer

2. Nobel Prize in Chemistry (1991) awarded to Richard Ernst for: The development of high resolution nuclear magnetic resonance (NMR) spectroscopy

Rejection: "The paper that described our achievements was rejected twice by the Journal of Chemical Physics to be finally accepted and published in the Review of Scientific Instruments"

Richard Ernst

3. Nobel Prize in Physics (1969) awarded to Murray Gell-Mann for: "for his contributions and discoveries concerning the classification of elementary particles and their interactions"

Rejection: That was not my title, which was : Isotopic Spin and Curious Particles. Physical Review rejected "Curious Particles". I tried "Strange Particles", and they rejected that too. They insisted on : "New Unstable Particles". That was the only phrase sufficiently pompous for the editors of the Physical Review. I should say now that I have always hated the Physical Review Letters and almost twenty years ago I decided never again to publish in that journal, but in 1953 I was scarcely in a position to shop around.

Murray Gell-Mann

4. Nobel Prize in Medicine (1953) awarded to Hans Krebs for: The discovery of the citric acid cycle (aka the Krebs cycle)

Rejection letter from Nature to Hans Krebs. 

5. Nobel Prize in Physics (2000) awarded to Herbert Kroemer for: "Developing semiconductor heterostructures used in high-speed and opto-electronics"

Rejection: "I wrote up the idea and submitted the paper to Applied Physics Letters, where it was rejected. I was talked into not fighting the rejection, but to submit it to the Proceedings of the IEEE, where it was published, but ignored. I also wrote a patent, which is probably a better paper than the one in Proc. IEEE."

Herbert Kroemer

6. Nobel Prize in Chemistry (1986) awarded to John Polanyi for: elucidating the dynamics of chemical elementary processes.

Rejection: "Physical Review Letters rejected the paper as lacking scientific interest. Shortly thereafter they rejected T. Maiman's report of the first operating laser, on the same grounds. Polanyi read about this second rejection, quite by chance, while holidaying on an island in Georgian Bay. On returning to Toronto in September of 1960 he submitted the identical manuscript to the Journal of Chemical Physics, where it was promptly published."

John Polanyi

7. Nobel Prize in Chemistry (1993) awarded to Kary Mullis for: invention of the polymerase chain reaction (PCR) method

Rejection: "And Dan Koshland would be the editor of Science when my first PCR paper was rejected from that journal and also the editor when PCR was three years later proclaimed Molecule of the Year."

8. Nobel Prize in Medicine (1977) awarded to Rosalind Yalow for: invention of the radioimmunoassay (RIA).

Rejection: "For years after winning the Nobel Prize, Yalow proudly showed this rejection letter in her public presentations."

Rejection letter received by Dr. Bradley and Dr. Yalow. 

Today, authors have the ability to upload their manuscript to places like Authorea and communicate their ideas prior to formal publication. This allows new and potentially breakthrough ideas to be discussed transparently. We think good science is science that can be scrutinized transparently--we're facilitating that. Join us!

References: François Jacob. Of flies, mice, and men. 158 p. (1998).

Which Drug Interactions Matters a lot in Older Adults?

Conventional wisdom has it that the elderly are at greater risk for adverse drug interactions, and the published evidence supports this view. Older patients take more medications and experience physiologic changes that may affect drug disposition, making them potentially more susceptible to the adverse outcomes from drug interactions. 

Over the past decade or so, we have also accumulated some useful data on which specific drug interactions increase the risk of serious reactions in older patients. In a recent paper, Hines and Murphy from the University of Arizona reviewed population-based studies over the past 10 years, and discussed those that detected serious adverse outcomes due to particular drug interactions. The Table lists the interactions found to result in either increased risk of hospitalization or death. It is important to remember that the interactions in the Table are the ones that were chosen for study, and other related interactions involving these drugs are also likely to increase the risk of serious adverse outcomes. For example, angiotensin receptor blockers may also increase the risk of hyperkalemia when combined with potassium-sparing diuretics or co-trimoxazole; combining calcium-channel blockers with cytochrome P450 (CYP) 3A4 inhibitors other than macrolides may increase the risk of hypotension or shock; digoxin toxicity may occur with concurrent use of many P-glycoprotein inhibitors other than macrolides; and phenytoin toxicity can be produced by CYP2C9 inhibitors other than co-trimoxazole.

Clinical evidence also suggests that a number of other oral antidiabetic agents are metabolized by CYP2C9 and CYP3A4, and hypoglycemia may occur when inhibitors of these isozymes are given concurrently; CYP2D6 inhibitors other than paroxetine may inhibit the efficacy of tamoxifen in breast cancer; CYP1A2 inhibitors other than ciprofloxacin can cause theophylline toxicity; and any CYP2C9 inhibitor would be expected to increase the anticoagulant response to warfarin. Moreover, the elderly may take many other drugs that have substantial risk of drug interactions, especially psychotherapeutic drugs, but also drugs such as colchicine, statins, drugs for Parkinson’s disease, cholinesterase inhibitors for Alzheimer’s disease, and nonsteroidal anti-inflammatory drugs. The vast majority of publications on drug–drug interactions are either case reports or pharmacokinetic studies in healthy subjects. Such data provide evidence that a drug interaction exists, but seldom give us information on how often adverse consequences occur or how severe they are likely to be. The value of the population-based studies discussed above is that they help us determine which drug interactions actually can result in severe adverse consequences, and give us some idea of the incidence of the adverse outcomes. 

References:

1. Drs. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. 
2. For an electronic version of this article, including references if any, visit www.hanstenandhorn.com.